منابع مشابه
Hypertension, Platelets, and the Endothelium
Platelets are the smallest of the blood cells, yet they are one of the main players during the process of thrombus formation (thrombogenesis). Furthermore, the traditional belief that the endothelium exists simply to provide an inert interface between the blood and the vessel wall is no longer accurate. Indeed, the endothelium produces a large number of substances that affect blood flow and in ...
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Interactions between the vessel wall and platelets or leukocytes were traditionally thought to be separate cellular adhesive contributions to either coagulation or inflammation. Platelets, in response to vessel wall injury, adhere to components of the extracellular matrix (ECM), which triggers sudden platelet activation and platelet plug formation. Initial responses are followed by coagulant ac...
متن کاملAntigenic relationship between blood platelets and vascular endothelium.
S ENSITIZATION of animals with allogeneic blood platelets induces accelerated rejection of allogeneic skin as well as renal grafts.2 In the latter instance the histologic lesions of the rejected graft were described as primarily vascular. These as well as earlier observations have suggested that an antigenic relationship exists between blood platelets and vascular endothelium. The experiments t...
متن کاملArachidonic Acid Metabolism in Human Platelets and Endothelium
Aspirin has been on the market for 115 years. Beginning with the marketing of indomethacin for the treatment of rheumatoid arthritis in 1963, at least 20 other nonsteroidal anti-inflammatory drugs (NSAIDs) with aspirin-like actions have been developed over the past 50 years, culminating with the introduction of a new class of selective inhibitors of cyclooxygenase (COX)-2, the coxibs, approxima...
متن کاملHypertension, platelets, and the endothelium: the "thrombotic paradox" of hypertension (or "Birmingham paradox") revisited.
Platelets are the smallest of the blood cells, yet they are one of the main players during the process of thrombus formation (thrombogenesis). Furthermore, the traditional belief that the endothelium exists simply to provide an inert interface between the blood and the vessel wall is no longer accurate. Indeed, the endothelium produces a large number of substances that affect blood flow and in ...
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ژورنال
عنوان ژورنال: JACC: Basic to Translational Science
سال: 2021
ISSN: ['2452-302X']
DOI: https://doi.org/10.1016/j.jacbts.2021.01.009